Name: Human S1PR5-Strep full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP120464

Tag	C-Flag&Strep Tag
Target	S1PR5
Synonyms	EDG8, Edg-8, S1P5, SPPR-1, SPPR-2
Description	Human S1PR5-Strep full length protein-synthetic nanodisc
Delivery	6~8weeks
Uniprot ID	Q9H228
Expression Host	HEK293
Protein Families	GPCR,Transmembrane,Druggable Genome,
Protein Pathways	S1P Signaling,
Molecular Weight	The human full length S1PR5-Strep protein has a MW of 41.8 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
Usage	Research use only
Conjugate	Unconjugated

Human S1PR5-Strep full length protein-synthetic nanodisc