Name: Human GPR62-Strep full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP120315

Tag	C-Flag&Strep Tag
Target	GPR62
Synonyms	GPCR8, KPG_005
Description	Human GPR62-Strep full length protein-synthetic nanodisc
Delivery	6~8weeks
Uniprot ID	Q9BZJ7
Expression Host	HEK293
Protein Families	GPCR,Transmembrane,Druggable Genome,
Protein Pathways	GPCRDB Other,
Molecular Weight	The human full length GPR62-Strep protein has a MW of 37.6 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with pH lower than 6.5 in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).[UniProtKB/Swiss-Prot Function]
Usage	Research use only
Conjugate	Unconjugated

Human GPR62-Strep full length protein-synthetic nanodisc