Name: Human GALR1-Strep full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP120253

Tag	C-Flag&Strep Tag
Target	GALR1
Synonyms	GALNR, GALNR1
Description	Human GALR1-Strep full length protein-synthetic nanodisc
Delivery	6~8weeks
Uniprot ID	P47211
Expression Host	HEK293
Protein Families	Transmembrane,Druggable Genome,
Protein Pathways	GPCRDB Class A Rhodopsin-like,Peptide GPCRs,Metabolic and Obesity,
Molecular Weight	The human full length GALR1-Strep protein has a MW of 39 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with pH lower than 6.5 in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]
Usage	Research use only
Conjugate	Unconjugated

Human GALR1-Strep full length protein-synthetic nanodisc