Target | |
---|---|
Synonyms | CD120b;p75;p75TNFR;TBPII;TNF-R-II;TNF-R75;TNFBR;TNFR1B;TNFR2;TNFR80 |
Description | Recombinant Human TNFRSF1B Protein with C-terminal human Fc tag |
Delivery | In Stock |
Uniprot ID | P20333 |
Expression Host | HEK293 |
Tag | C-Human Fc Tag |
Molecular Characterization | TNFRSF1B(Leu23-Asp257) hFc(Glu99-Ala330) |
Molecular Weight | The protein has a predicted molecular mass of 51.3 kDa after removal of the signal peptide. The apparent molecular mass of TNFRSF1B-hFc is approximately 55-70kDa due to glycosylation. |
Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008] |
Usage | Research use only |
Human TNFRSF1B Protein, hFc Tag
Price: 10μg ¥600.00 ; 50μg ¥2199.00 ; 100μg ¥3299.00
Product Data
图片
Figure 1. Human TNFRSF1B Protein, hFc Tag on SDS-PAGE under reducing condition.
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