Name: Human SHKB1 full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP100707

Tag	C-Flag Tag
Target	SHKB1
Synonyms	PP203, Sb1
Description	Human SHKB1 full length protein-synthetic nanodisc
Delivery	6~8weeks
Uniprot ID	Q8TBC3
Expression Host	HEK293
Protein Families	Ion Channels: Other
Protein Pathways	N/A
Molecular Weight	The human full length SHKB1 protein has a MW of 76.3kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.[UniProtKB/Swiss-Prot Function]
Usage	Research use only
Conjugate	Unconjugated

Human SHKB1 full length protein-synthetic nanodisc