Name: Human SCN5A full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP100726

Tag	C-Flag Tag
Target	SCN5A
Synonyms	CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1
Description	Human SCN5A full length protein-synthetic nanodisc
Delivery	In Stock
Uniprot ID	Q14524
Expression Host	HEK293
Protein Families	Druggable Genome, Ion Channels: Sodium, Transmembrane
Protein Pathways	N/A
Molecular Weight	The human full length SCN5A protein has a MW of 226.9 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	The protein is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease.
Usage	Research use only
Conjugate	Unconjugated

Human SCN5A full length protein-synthetic nanodisc