Target | |
---|---|
Synonyms | FGCP;FOLH;GCP2;GCPII;mGCP;NAALAD1;NAALAdase;PSM;PSMA |
Description | Recombinant human PSMA protein with N-terminal human Fc tag |
Delivery | In Stock |
Uniprot ID | Q04609 |
Expression Host | HEK293 |
Tag | N-Human Fc Tag |
Molecular Characterization | hFc(Glu99-Ala330) PSMA(Lys44-Ala750) |
Molecular Weight | The protein has a predicted molecular mass of 105.7 kDa after removal of the signal peptide.The apparent molecular mass of hFc-PSMA is approximately 130 kDa due to glycosylation. |
Purity | The purity of the protein is greater than 90% as determined by SDS-PAGE and Coomassie blue staining. |
Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background | This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. |
Usage | Research use only |
Human PSMA Protein, hFc Tag
Price: 10μg ¥727.00 ; 50μg ¥2666.00 ; 100 μg ¥3999.00
Product Data
图片
Figure 1. Human PSMA Protein, hFc Tag on SDS-PAGE under reducing condition.
Figure 2. ELISA plate pre-coated by 2 μg/mL (100 μL/well) Human PSMA Protein, hFc Tag (PME100390) can bind Anti-PSMA(rosopatamab biosimilar) mAb (BME100128) in a linear range of 3.20–80 ng/mL.
相关产品
Biosimilar reference antibodies
SKU: BME100128B Target: PSMA
Application: ELISA; Flow Cyt
Price: 50 μg ¥890.00 ; 100 μg ¥1699.00
ECD Proteins
SKU: PME-M100103 Target: PSMA
Price: 10μg ¥690.00 ; 50μg ¥2500.00 ; 100μg ¥3699.00
ECD Proteins
SKU: PME100545 Target: PSMA
Price: 10μg ¥854.00 ; 50μg ¥3133.00 ; 100 μg ¥4699.00
ECD Proteins
SKU: PME100546 Target: PSMA
Price: 10μg ¥782.00 ; 50μg ¥2866.00 ; 100 μg ¥4299.00
ECD Proteins
SKU: PME-C100035 Target: PSMA
Price: 10μg ¥799.00; 50μg ¥2666.00 ; 100 μg ¥3999.00