Name: Human GLP1R-Strep full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP120121

Tag	C-Flag&Strep Tag
Target	GLP1R
Synonyms	GLP-1; GLP-1-R; GLP-1R
Description	Human GLP1R-Strep full length protein-synthetic nanodisc
Delivery	6~8weeks
Uniprot ID	P43220
Expression Host	HEK293
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction
Molecular Weight	The human full length GLP1R-Strep protein has a MW of 53 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	A 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
Usage	Research use only
Conjugate	Unconjugated

Human GLP1R-Strep full length protein-synthetic nanodisc

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Human GLP1R-Strep full length protein-synthetic nanodisc

Product Data

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