Human GIPR full length protein-synthetic nanodisc

Name: Human GIPR full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP100130
Price: 8000.00 CNY
Availability: InStock

Price: 10 μg ￥6300.00 ;50 μg ￥30000.00 ; 100 μg ￥55000.00

SKU: FLP100130 Category: Full Length Transmembrane Proteins Tag: synthetic nanodisc

Datasheet

MSDS

Product Data

Tag	C-Flag Tag
Target	GIPR
Synonyms	PGQTL2
Description	Human GIPR full length protein-synthetic nanodisc
Delivery	In Stock
Uniprot ID	P48546
Expression Host	HEK293
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction
Molecular Weight	The human full length GIPR protein has a MW of 53.2 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	A G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
Usage	Research use only
Conjugate	Unconjugated

图片

Figure 1. Elisa plates were pre-coated with Flag Tag GIPR-Nanodisc (0.2μg/per well). Serial diluted anti-GIPR monoclonal antibody (BME100209) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-GIPR monoclonal antibody binding with GIPR-Nanodisc is 862.5ng/ml.
FLP100130-GIPR-Fig.2-SDS-PAGE-1.jpg
Figure 2. Human GIPR-Nanodisc, Flag Tag on SDS-PAGE

Human GIPR full length protein-synthetic nanodisc

Product Data

图片

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