Name: Human FZD7-Strep full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP120109

Tag	C-Flag&Strep Tag
Target	FZD7
Synonyms	FzE3
Description	Human FZD7-Strep full length protein-synthetic nanodisc
Delivery	6~8weeks
Uniprot ID	O75084
Expression Host	HEK293
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway
Molecular Weight	The human full length FZD7-Strep protein has a MW of 63.6 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with pH lower than 6.5 in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C(Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
Usage	Research use only
Conjugate	Unconjugated

Human FZD7-Strep full length protein-synthetic nanodisc

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Human FZD7-Strep full length protein-synthetic nanodisc

Product Data

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