Human FZD4 full length protein-synthetic nanodisc

Name: Human FZD4 full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP100139
Price: 8000.00 CNY
Availability: InStock

Price: 10 μg ￥6300.00 ;50 μg ￥30000.00 ; 100 μg ￥55000.00

SKU: FLP100139 Category: Full Length Transmembrane Proteins Tag: synthetic nanodisc

Datasheet

MSDS

Product Data

Tag	C-Flag Tag
Target	FZD4
Synonyms	CD344; EVR1; FEVR; Fz-4; Fz4; FZD4S; FzE4; GPCR; hFz4
Description	Human FZD4 full length protein-synthetic nanodisc
Delivery	In Stock
Uniprot ID	Q9ULV1
Expression Host	HEK293
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway
Molecular Weight	The human full length FZD4 protein has a MW of 60.3 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with pH lower than 6.5 in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	A member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.
Usage	Research use only
Conjugate	Unconjugated

图片

elisa-FLP100139 FZD4 Fig.1 Elisa 1
Figure1. Elisa plates were pre-coated with Flag Tag FZD4-Nanodisc (0.2μg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with FZD4-Nanodisc is 1.843ng/ml.
page-FLP100139 FZD4 Fig.2 SDS PAGE 1
Figure2. Human FZD4-Nanodisc, Flag Tag on SDS-PAGE

Human FZD4 full length protein-synthetic nanodisc

Product Data

图片

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