Name: Human DRD4 full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP100232

Tag	C-Flag Tag
Target	DRD4
Synonyms	D4DR
Description	Human DRD4 full length protein-synthetic nanodisc
Delivery	6~8weeks
Uniprot ID	P21917
Expression Host	HEK293
Protein Families	GPCR,Transmembrane,Druggable Genome,
Protein Pathways	GPCRDB Class A Rhodopsin-like,GPCRDB Other,Monoamine GPCRs,
Molecular Weight	The human full length DRD4 protein has a MW of 43.9kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
Usage	Research use only
Conjugate	Unconjugated

Human DRD4 full length protein-synthetic nanodisc