Human CXCR2-Strep full length protein-synthetic nanodisc

Name: Human CXCR2-Strep full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP120066

Price: 10 μg ￥5670.00 ;50 μg ￥27000.00 ; 100 μg ￥49500.00

SKU: FLP120066 Category: Full Length Transmembrane Proteins

Datasheet

MSDS

Product Data

Tag	C-Flag&Strep Tag
Target	CXCR2
Synonyms	CD182; CDw128b; CMKAR2; IL8R2; IL8RA; IL8RB
Description	Human CXCR2-Strep full length protein-synthetic nanodisc
Delivery	6~8weeks
Uniprot ID	P25025
Expression Host	HEK293
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection
Molecular Weight	The human full length CXCR2-Strep protein has a MW of 40.8 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with pH lower than 6.5 in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	The protein is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.
Usage	Research use only
Conjugate	Unconjugated

Human CXCR2-Strep full length protein-synthetic nanodisc

Product Data

图片

相关产品

Login