Human CGRPR-RAMP1 full length protein-MNP

Name: Human CGRPR-RAMP1 full length protein-MNP - 专注肿瘤免疫
SKU: FLP200145
Price: 1600.00 CNY
Availability: InStock

Price: 50 μg ￥8000.00 ; 100 μg ￥10800.00

SKU: FLP200145 Category: Full Length Transmembrane Proteins

Datasheet

MSDS

Product Data

Target	CGRPR
Synonyms	CALCRL; CRLR; LMPHM8
Description	Human CGRPR-RAMP1 full length protein membrane nanoparticles (MNPs)
Delivery	In Stock
Uniprot ID	Q16602
Expression Host	HEK293
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction
Molecular Weight	The human full length CGRPR protein has a MW of 53.0 kDa
Formulation & Reconstitution	Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	The CGRP receptor (CGRPR) is a member of family B G protein coupled receptors (GPCRs), is expressed throughout the trigeminal system, including neurons and endothelial cells. They usually function with accessory proteins such as receptor activity modifying proteins (RAMPs) and Na/H exchange regulatory factors (NHERFs). CGRPR is a heterodimer complex of the calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1). Therapeutics for migraine treatment are mostly targeting CRLR-RAMP1 protein-protein interaction surfaces, thereby blocking CGRP activity.
Usage	Research use only
Conjugate	Unconjugated

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elisa-FLP200145 CGRPR RAMP1 Fig.1 Elisa 1
Figure1. Elisa plates were pre-coated with 0.5μg/per well purified human CGRPR-RAMP1 full length membrane nanoparticles. Serial diluted anti-CGRPR monoclonal antibody (BME100166) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-CGRPR monoclonal antibody binding with CGRPR-RAMP1 full length membrane nanoparticles is 122.8ng/ml.

Human CGRPR-RAMP1 full length protein-MNP

Product Data

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