Biotinylated Human CLDN18.2 full length protein-synthetic nanodisc

Name: Biotinylated Human CLDN18.2 full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP100014B

Price: 10 μg ￥6930.00 ; 50 μg ￥33000.00 ; 100 μg ￥60500.00

SKU: FLP100014B Category: Full Length Transmembrane Proteins

Datasheet

MSDS

Product Data

Tag	Biotinylated, C-Flag&Avi Tag
Target	CLDN18.2
Synonyms	Claudin 18.2
Description	Biotinylated Human CLDN18.2 full length protein-synthetic nanodisc
Delivery	In Stock
Uniprot ID	P56856-2
Expression Host	HEK293
Protein Families	Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction
Molecular Weight	The human full length CLDN18.2 Protein has a MW of 32.5 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
Usage	Research use only
Conjugate	Biotinylated

图片

flp100014b-cldn18.2-elisa1.jpg
Figure 1. ELISA plate pre-coated by 2 μg/mL (100 μL/well) Anti-CLDN18.2 antibody(DM179); Rabbit mAb (DME100179) can bind Biotinylated Human CLDN18.2 full length protein-synthetic nanodisc (FLP100014B) in a linear range of 40–5000 ng/mL. In order to specifically detect FLP100014B, HRP Conjugated Streptavidin was used as detection antibody.
flp100014b-cldn18.2-sp1.jpg
Figure 2. Biotinylated Human CLDN18.2-Nanodisc, Flag Tag on SDS-PAGE

Biotinylated Human CLDN18.2 full length protein-synthetic nanodisc

Product Data

图片

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