Clone ID | 1H2 |
---|---|
Target | |
Synonyms | N.A. |
Host Species | Rabbit |
Description | Biotinylated Anti-CL2A(ADC linker) antibody(1H2); Rabbit mAb |
Delivery | 2-3 weeks |
Uniprot ID | N.A. |
IgG type | Rabbit IgG |
Clonality | Monoclonal |
Reactivity | N.A. |
Applications | ELISA |
Recommended Dilutions | ELISA 1:5000-10000 |
Purification | Purified from cell culture supernatant by affinity chromatography |
Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background | CL2A is a crucial component in antibody-drug conjugate (ADC) therapy, acting as a chemical linker that connects a potent DNA topoisomerase I inhibitor, SN-38, to an antibody. Representing Cysteine-Linked 2-Aminoethyl, CL2A features a complex structure with a PEG8 chain, a triazole ring, a PABC-peptide, and a maleimide group. The maleimide group binds to a cysteine residue on the antibody, facilitating targeted drug delivery. Designed to release SN-38 in acidic cancer cell environments, CL2A induces DNA damage and cell death. This versatile linker is employed in ADCs targeting various antigens like Trop-2 or HER2, tailored to specific cancer types. |
Usage | Research use only |
![Awaiting product image](https://www.dimabio.cn/wp-content/uploads/woocommerce-placeholder-400x400.png)
Biotinylated Anti-CL2A(ADC linker) antibody(1H2); Rabbit mAb
Price: 10μg ¥1030.00 ; 50μg ¥3380.00 ; 100 μg ¥6080.00 ; 500 μg ¥19880.00
Product Data
图片
相关产品
Monoclonal Antibodies
Biotinylated Anti-CL2A(ADC linker) antibody(1H6); Rabbit mAb
SKU: DME101021B Target: CL2A
Application: ELISA
Price: 10μg ¥1030.00 ; 50μg ¥3380.00 ; 100 μg ¥6080.00 ; 500 μg ¥19880.00
Monoclonal Antibodies
SKU: DME101022 Target: CL2A
Application: ELISA
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
Monoclonal Antibodies
SKU: DME101021 Target: CL2A
Application: ELISA
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
Monoclonal Antibodies
SKU: DME101023 Target: CL2A
Application: ELISA
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
Monoclonal Antibodies
Biotinylated Anti-CL2A(ADC linker) antibody(1G9); Rabbit mAb
SKU: DME101022B Target: CL2A
Application: ELISA
Price: 10μg ¥1030.00 ; 50μg ¥3380.00 ; 100 μg ¥6080.00 ; 500 μg ¥19880.00