Clone ID | DMC271 |
---|---|
Target | |
Synonyms | IL-1; IL1-BETA; IL1F2 |
Host Species | Rabbit |
Description | Anti-IL1B antibody(DMC271); IgG1 Chimeric mAb |
Delivery | In Stock |
Uniprot ID | P01584 |
IgG type | Rabbit/Human Fc chimeric IgG1 |
Clonality | Monoclonal |
Reactivity | Human |
Applications | Flow Cyt |
Recommended Dilutions | Flow Cyt 1:100 |
Purification | Purified from cell culture supernatant by affinity chromatography |
Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein; which is proteolytically processed to its active form by caspase 1 (CASP1:ICE). This cytokine is an important mediator of the inflammatory response; and is involved in a variety of cellular activities; including cell proliferation; differentiation; and apoptosis. The induction of cyclooxygenase-2 (PTGS2:COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. Similarly; IL-1B has been implicated in human osteoarthritis pathogenesis. Patients with severe Coronavirus Disease 2019 (COVID-19) present elevated levels of pro-inflammatory cytokines such as IL-1B in bronchial alveolar lavage fluid samples. The lung damage induced by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent; a result of the inflammatory response promoted by cytokines such as IL-1B. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. |
Usage | Research use only |
Anti-IL1B antibody(DMC271); IgG1 Chimeric mAb
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
Product Data
图片
Figure 1. Flow cytometry analysis with Anti-IL1B (DMC271) on Expi293 cells transfected with human IL1B (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
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