Anti-HBEGF antibody(DMC500); IgG1 Chimeric mAb

Name: Anti-HBEGF antibody(DMC500); IgG1 Chimeric mAb - 专注肿瘤免疫
SKU: DMC100500

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

SKU: DMC100500 Category: Monoclonal Antibodies

Datasheet

MSDS

Product Data

Clone ID	DMC500
Target	HBEGF
Synonyms	DTR; DTS; DTSF; HEGFL
Host Species	Rabbit
Description	Anti-HBEGF antibody(DMC500); IgG1 Chimeric mAb
Delivery	In Stock
Uniprot ID	Q99075
IgG type	Rabbit/Human Fc chimeric IgG1
Clonality	Monoclonal
Reactivity	Human
Applications	Flow Cyt
Recommended Dilutions	Flow Cyt 1:100
Purification	Purified from cell culture supernatant by affinity chromatography
Formulation & Reconstitution	Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	Growth factor that mediates its effects via EGFR; ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts; but not endothelial cells. It is able to bind EGF receptor:EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.[UniProtKB:Swiss-Prot Function]
Usage	Research use only
Conjugate	Unconjugated
DIMA Disclaimer	All DIMA recombinant antibodies are genuinely generated by DIMA Biotech. They are all under patent application. Any protein sequencing or reverse engineering attempt is prohibited. We are actively scrutinizing all patent application to ensure no IP infringement.

图片

DMC100500-HBEGF-Fig.1-FC-1.jpg
Figure 1. Flow cytometry analysis with Anti-HBEGF(DMC500) on Expi293 cells transfected with human HBEGF (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).

Figure 2. Flow cytometry analysis of antigen binding of anti-human HBEGF mAb(DMC100500).
(A) DMC100500 does not bind to CHO-S cells that do not express HBEGF.
(B) A clear peak shift of DMC100500 was seen compared to the control when incubated with HBEGF-expressing MDA-MB-231 cells, indicating strong binding of DMC100500 to HBEGF. Antibodies were incubated at 5 μg/mL.

Anti-HBEGF antibody(DMC500); IgG1 Chimeric mAb

Product Data

图片

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