Clone ID | DMC500 |
---|---|
Target | |
Synonyms | DTR; DTS; DTSF; HEGFL |
Host Species | Rabbit |
Description | Anti-HBEGF antibody(DMC500); IgG1 Chimeric mAb |
Delivery | In Stock |
Uniprot ID | Q99075 |
IgG type | Rabbit/Human Fc chimeric IgG1 |
Clonality | Monoclonal |
Reactivity | Human |
Applications | Flow Cyt |
Recommended Dilutions | Flow Cyt 1:100 |
Purification | Purified from cell culture supernatant by affinity chromatography |
Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background | Growth factor that mediates its effects via EGFR; ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts; but not endothelial cells. It is able to bind EGF receptor:EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.[UniProtKB:Swiss-Prot Function] |
Usage | Research use only |
Anti-HBEGF antibody(DMC500); IgG1 Chimeric mAb
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
Product Data
图片
Figure 1. Flow cytometry analysis with Anti-HBEGF(DMC500) on Expi293 cells transfected with human HBEGF (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
Figure 2. Flow cytometry analysis of antigen binding of anti-human HBEGF mAb(DMC100500).
(A) DMC100500 does not bind to CHO-S cells that do not express HBEGF.
(B) A clear peak shift of DMC100500 was seen compared to the control when incubated with HBEGF-expressing MDA-MB-231 cells, indicating strong binding of DMC100500 to HBEGF. Antibodies were incubated at 5 μg/mL.
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