Clone ID | 1G2 |
---|---|
Target | |
Synonyms | CD3e;T3E |
Host Species | Rabbit |
Description | Anti-CD3E antibody(1G2), IgG1 Chimeric mAb |
Delivery | In Stock |
Uniprot ID | P07766 |
IgG type | Rabbit/Human Fc chimeric IgG1 |
Clonality | Monoclonal |
Reactivity | Human |
Applications | Flow Cyt |
Recommended Dilutions | Flow Cyt 1/100 |
Purification | Purified from cell culture supernatant by affinity chromatography |
Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background | The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008] |
Usage | Research use only |
Anti-CD3E antibody(1G2), IgG1 Chimeric mAb
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
Product Data
图片
Figure 1. Flow cytometry analysis with 1μg/mL Anti-CD3E (1G2) mAb on Jurkat cells.
Figure 2. Flow cytometry analysis of antigen binding of anti-human CD3E mAb(DMC101085).
(A) DMC101085 does not bind to 293T cells that do not express CD3E.
(B) A clear peak shift of DMC101085 was seen compared to the control when incubated with CD3E-expressing Jurkat cells, indicating strong binding of DMC101085 to CD3E. Antibodies were incubated at 5 μg/mL.
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