Anti-CCR6 antibody(DMC477); IgG1 Chimeric mAb

Name: Anti-CCR6 antibody(DMC477); IgG1 Chimeric mAb - 专注肿瘤免疫
SKU: DMC100477

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

SKU: DMC100477 Category: Monoclonal Antibodies

Datasheet

MSDS

Product Data

Clone ID	DMC477
Target	CCR6
Synonyms	BN-1; C-C CKR-6; CC-CKR-6; CCR-6; CD196; CKR-L3; CKRL3; CMKBR6; DCR2; DRY6; GPR29; GPRCY4; STRL22
Host Species	Rabbit
Description	Anti-CCR6 antibody(DMC477); IgG1 Chimeric mAb
Delivery	In Stock
Uniprot ID	P51684
IgG type	Rabbit/Human Fc chimeric IgG1
Clonality	Monoclonal
Reactivity	Human
Applications	Flow Cyt
Recommended Dilutions	Flow Cyt 1:100
Purification	Purified from cell culture supernatant by affinity chromatography
Formulation & Reconstitution	Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	This gene encodes a member of the beta chemokine receptor family; which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation; and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq; Jul 2008]
Usage	Research use only
Conjugate	Unconjugated

图片

DMC100477-CCR6-Fig.1-FC-1.jpg
Figure 1. CCR6 protein is highly expressed on the surface of Expi293 cell membrane. Flow cytometry analysis with Anti-CCR6 (DMC477) on Expi293 cells transfected with human CCR6 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram), and Isotype antibody on Expi293 transfected with irrelevant protein (Orange histogram).

Figure 2. Flow cytometry analysis of antigen binding of anti-human CCR6 mAb( DMC100477).
(A) DMC100477 does not bind to CHO-S cells that do not express CCR6.
(B) A clear peak shift of DMC100477 was seen compared to the control when incubated with CCR6-expressing Huh7 cells, indicating strong binding of DMC100477 to CCR6. Antibodies were incubated at 5 μg/mL.

Anti-CCR6 antibody(DMC477); IgG1 Chimeric mAb

Product Data

图片

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