Human CXCR3 full length protein-synthetic nanodisc

Name: Human CXCR3 full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP100053
Price: 8000.00 CNY
Availability: InStock

Price: 10 μg ￥6300.00 ;50 μg ￥30000.00 ; 100 μg ￥55000.00

SKU: FLP100053 Category: Full Length Transmembrane Proteins Tag: synthetic nanodisc

Datasheet

MSDS

Product Data

Tag	C-Flag Tag
Target	CXCR3
Synonyms	CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10-R; Mig-R; MigR
Description	Human CXCR3 full length protein-synthetic nanodisc
Delivery	In Stock
Uniprot ID	P49682
Expression Host	HEK293
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Chemokine signaling pathway, Cytokine-cytokine receptor interaction
Molecular Weight	The human full length CXCR3 protein has a MW of 40.6 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	A G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4.
Usage	Research use only
Conjugate	Unconjugated

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elisa-FLP100053 CXCR3 Fig.1 Elisa 1
Figure1. Elisa plates were pre-coated with Flag Tag CXCR3-Nanodisc (0.2μg/per well). Serial diluted anti-CXCR3 monoclonal antibody (DME100208) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-CXCR3 monoclonal antibody binding with CXCR3-Nanodisc is 15.79ng/ml.
page-FLP100053 CXCR3 Fig.2 SDS PAGE 1
Figure2. WB analysis of Human CXCR3-Nanodisc with anti-Flag monoclonal antibody at 1/5000 dilution, followed by Goat Anti-Rabbit IgG HRP at 1/5000 dilution

Human CXCR3 full length protein-synthetic nanodisc

Product Data

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