Human CCR4 full length protein-synthetic nanodisc

Name: Human CCR4 full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP100024
Price: 8000.00 CNY
Availability: InStock

Price: 10 μg ￥6300.00 ;50 μg ￥30000.00 ; 100 μg ￥55000.00

SKU: FLP100024 Category: Full Length Transmembrane Proteins Tag: synthetic nanodisc

Datasheet

MSDS

Product Data

Tag	C-Flag Tag
Target	CCR4
Synonyms	CC-CKR-4; CD194; ChemR13; CKR4; CMKBR4
Description	Human CCR4 full length protein-synthetic nanodisc
Delivery	In Stock
Uniprot ID	P51679
Expression Host	HEK293
Protein Families	GPCR
Protein Pathways	Chemokine signaling pathway, Cytokine-cytokine receptor interaction
Molecular Weight	The human full length CCR4 Protein has a MW of 41.4 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	The protein belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine – MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.
Usage	Research use only
Conjugate	Unconjugated

图片

elisa-FLP100024 CCR4 Fig.1 Elisa 1
Figure1. Elisa plates were pre-coated with Flag Tag CCR4-Nanodisc (0.2μg/per well). Serial diluted anti-CCR4 monoclonal antibody (BME100086) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-CCR4 monoclonal antibody binding with CCR4-Nanodisc is 40.3ng/ml.
page-FLP100024 CCR4 Fig.2 SDS PAGE 1
Figure2. Human CCR4-Nanodisc, Flag Tag on SDS-PAGE

Human CCR4 full length protein-synthetic nanodisc

Product Data

图片

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