Human SCAP full length protein-synthetic nanodisc

Name: Human SCAP full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP100498

Price: 10 μg ￥6300.00 ; 50 μg ￥30000.00 ; 100 μg ￥55000.00

SKU: FLP100498 Category: Full Length Transmembrane Proteins

Datasheet

MSDS

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Tag	C-Flag Tag
Target	SCAP
Synonyms	N/A
Description	Human SCAP full length protein-synthetic nanodisc
Delivery	In Stock
Uniprot ID	Q12770
Expression Host	HEK293
Protein Families	Druggable Genome, Transcription Factors, Transmembrane
Protein Pathways	N/A
Molecular Weight	The human full length SCAP protein has a MW of 139.7 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	A protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis.
Usage	Research use only
Conjugate	Unconjugated

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Figure 1. Elisa plates were pre-coated with Flag Tag SCAP-Nanodisc (0.2μg/per well). Serial diluted anti-Flag monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-Flag monoclonal antibody binding with SCAP-Nanodisc is 5.795ng/ml.

Figure 2. Human SCAP-Nanodisc, Flag Tag on SDS-PAGE

Human SCAP full length protein-synthetic nanodisc

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