Name: Human LGR4-Strep full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP120072

Tag	C-Flag&Strep Tag
Target	LGR4
Synonyms	BNMD17; GPR48
Description	Human LGR4-Strep full length protein-synthetic nanodisc
Delivery	6~8weeks
Uniprot ID	Q9BXB1
Expression Host	HEK293
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	N/A
Molecular Weight	The human full length LGR4-Strep protein has a MW of 104.5 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with pH lower than 6.5 in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye.
Usage	Research use only
Conjugate	Unconjugated

Human LGR4-Strep full length protein-synthetic nanodisc

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Human LGR4-Strep full length protein-synthetic nanodisc

Product Data

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