Name: Human CCR7-Strep full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP120060

Tag	C-Flag&Strep Tag
Target	CCR7
Synonyms	BLR2; CC-CKR-7; CCR-7; CD197; CDw197; CMKBR7; EBI1
Description	Human CCR7-Strep full length protein-synthetic nanodisc
Delivery	6~8weeks
Uniprot ID	P32248
Expression Host	HEK293
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Chemokine signaling pathway, Cytokine-cytokine receptor interaction
Molecular Weight	The human full length CCR7-Strep protein has a MW of 42.9 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with pH lower than 6.5 in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	The protein is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis.
Usage	Research use only
Conjugate	Unconjugated

Human CCR7-Strep full length protein-synthetic nanodisc

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Human CCR7-Strep full length protein-synthetic nanodisc

Product Data

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