Name: Human KCTD6 full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP100716

Tag	C-Flag Tag
Target	KCTD6
Synonyms	KCASH3
Description	Human KCTD6 full length protein-synthetic nanodisc
Delivery	6~8weeks
Uniprot ID	Q8NC69
Expression Host	HEK293
Protein Families	Ion Channels: Other
Protein Pathways	N/A
Molecular Weight	The human full length KCTD6 protein has a MW of 27.6kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).[UniProtKB/Swiss-Prot Function]
Usage	Research use only
Conjugate	Unconjugated

Human KCTD6 full length protein-synthetic nanodisc

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Human KCTD6 full length protein-synthetic nanodisc

Product Data

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