Clone ID | DM125 |
---|---|
Target | |
Synonyms | CD217;CDw217;IL-17RA;IL17R;CANDF5;hIL-17R |
Host Species | Rabbit |
Description | Anti-IL17RA antibody(DM125); Rabbit mAb |
Delivery | In Stock |
Uniprot ID | Q96F46 |
IgG type | Rabbit IgG |
Clonality | Monoclonal |
Reactivity | Human |
Applications | Flow Cyt |
Recommended Dilutions | Flow Cyt 1:100 |
Purification | Purified from cell culture supernatant by affinity chromatography |
Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background | Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors; this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Usage | Research use only |
Anti-IL17RA antibody(DM125); Rabbit mAb
Price: 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
Product Data
图片
Figure 1. Flow cytometry analysis with Anti-IL-17RA (DM125) on Expi293 cells transfected with human IL17RA (Blue histogram)or Expi293 transfected with irrelevant protein (Red histogram).
Figure 2. Flow cytometry analysis of antigen binding of rabbit anti-human IL17RA mAb(DME100125).
(A) DME100125 does not bind to CHO-S cells that do not express IL17RA.
(B) A clear peak shift of DME100125 was seen compared to the control when incubated with IL17RA-expressing THP-1 cells, indicating strong binding of DME100125 to IL17RA. Antibodies were incubated at 5 μg/mL.
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