Name: Human MRGX1-Strep full length protein-synthetic nanodisc - 专注肿瘤免疫
SKU: FLP120351

Tag	C-Flag&Strep Tag
Target	MRGX1
Synonyms	GPCR, MGRG2, MRGX1, SNSR4
Description	Human MRGX1-Strep full length protein-synthetic nanodisc
Delivery	6~8weeks
Uniprot ID	Q96LB2
Expression Host	HEK293
Protein Families	GPCR,Transmembrane,Druggable Genome,
Protein Pathways	N/A
Molecular Weight	The human full length MRGX1-Strep protein has a MW of 36.3 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.[UniProtKB/Swiss-Prot Function]
Usage	Research use only
Conjugate	Unconjugated

Human MRGX1-Strep full length protein-synthetic nanodisc

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Human MRGX1-Strep full length protein-synthetic nanodisc

Product Data

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