Anti-HBEGF antibody(DMC500); IgG1 Chimeric mAb

Name: Anti-HBEGF antibody(DMC500); IgG1 Chimeric mAb - 专注肿瘤免疫
SKU: DMC100500

Price: 10μg ￥690.00 ; 50μg ￥2280.00 ; 100 μg ￥4080.00 ; 500 μg ￥13280.00

SKU: DMC100500 Category: Monoclonal Antibodies

Datasheet

MSDS

Product Data

Clone ID	DMC500
Target	HBEGF
Synonyms	DTR; DTS; DTSF; HEGFL
Host Species	Rabbit
Description	Anti-HBEGF antibody(DMC500); IgG1 Chimeric mAb
Delivery	In Stock
Uniprot ID	Q99075
IgG type	Rabbit/Human Fc chimeric IgG1
Clonality	Monoclonal
Reactivity	Human
Applications	Flow Cyt
Recommended Dilutions	Flow Cyt 1:100
Purification	Purified from cell culture supernatant by affinity chromatography
Formulation & Reconstitution	Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	Growth factor that mediates its effects via EGFR; ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts; but not endothelial cells. It is able to bind EGF receptor:EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.[UniProtKB:Swiss-Prot Function]
Usage	Research use only
Conjugate	Unconjugated

图片

DMC100500-HBEGF-Fig.1-FC-1.jpg
Figure 1. Flow cytometry analysis with Anti-HBEGF(DMC500) on Expi293 cells transfected with human HBEGF (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).

Figure 2. Flow cytometry analysis of antigen binding of anti-human HBEGF mAb(DMC100500).
(A) DMC100500 does not bind to CHO-S cells that do not express HBEGF.
(B) A clear peak shift of DMC100500 was seen compared to the control when incubated with HBEGF-expressing MDA-MB-231 cells, indicating strong binding of DMC100500 to HBEGF. Antibodies were incubated at 5 μg/mL.

Anti-HBEGF antibody(DMC500); IgG1 Chimeric mAb

Product Data

图片

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