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Human ACE2 Protein, mFc Tag
Catalog Number | PME100072 |
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Package | 10μg ¥727.00 ; 50μg ¥2666.00 ; 100 μg ¥3999.00 |
Description | Recombinant human ACE2 protein with C-terminal mouse Fc tag |
Synonyms | ACE-2, ACEH, ACE2 |
Delivery | In Stock |
Uniprot ID | Q9BYF1 |
Expression Host | HEK293 |
Tag | C-Mouse Fc tag |
Molecular Characterization |
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Molecular Weight | The protein has a predicted molecular mass of 109.7 kDa after removal of the signal peptide. |
Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
Storage | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized proteins are shipped at ambient temperature. |
Usage | Research use only |
Images |
Figure 1. Human ACE2 Protein, mFc Tag on SDS-PAGE under reducing condition.
Figure 2. ELISA plate pre-coated by 2 μg/ml (100 μl/well) S-RBD, hFc tagged protein (PME100487) can bind Human ACE2, mFc Tagged protein(PME100072) in a linear range of 0.976-39.35 ng/ml. |
Background | The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. |
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