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Human ACE2 Protein, hFc Tag

Catalog Number PME100073
Package 10μg ¥782.00 ; 50μg ¥2866.00 ; 100 μg ¥4299.00
Description Recombinant human ACE2 protein with C-terminal human Fc tag
Synonyms ACE-2,ACEH,ACE2
Delivery In Stock
Uniprot ID Q9BYF1
Expression Host HEK293
Tag C-Human Fc tag
Molecular Characterization 132456
Molecular Weight The protein has a predicted molecular mass of 109.7 kDa after removal of the signal peptide.
Purity The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Storage Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized proteins are shipped at ambient temperature.
Usage Research use only

Figure 1. Human ACE2 Protein, hFc Tag on SDS-PAGE under reducing condition.

Figure 2. ELISA plate pre-coated by 2 μg/ml (100 μl/well) S-RBD, mFc-His tagged protein (PME100460) can bind Human ACE2, hFc Tagged protein(PME100073) in a linear range of 0.488-49.83 ng/ml.

Background The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
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