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Anti-CD142 antibody(DMC463), IgG1 Chimeric mAb

Clone ID DMC463
Immunogen Recombinant human CD142(Ser33-Glu251) ( PME100751) produced by using human HEK293 cells
Buffer 1XPBS
Catalog Number DMC100463
Package 10μg ¥690.00 ; 50μg ¥2280.00 ; 100 μg ¥4080.00 ; 500 μg ¥13280.00
Delivery In Stock
Synonyms TF, Coagulation factor III, F3
Host Species Rabbit
IgG type Rabbit/Human Fc chimeric IgG1
Clonality Monoclonal
Formulation Liquid
Purification Purified from cell culture supernatant by affinity chromatography
Reactivity Human
Applications Flow Cyt
Recommended Dilutions Flow Cyt 1/100
Storage Store at -20°C for 12 months (Avoid repeated freezing and thawing)
Usage Research use only


Figure 1. Flow cytometry analysis with Anti-CD142 (DMC463) on Expi293 cells transfected with human CD142 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).

Background This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]
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